Marcadores bioquímicos, nutricionales y actividad antioxidante en el síndrome metabólico / Biochemical and nutritional markers and antioxidant activity in metabolic syndrome

ANTECEDENTES Y OBJETIVOS: 1) Valorar nutricionalmente la dieta seguida por los pacientes con síndrome metabólico, y 2) analizar bioquímicamente el nivel de oxidación-reducción en los pacientes con síndrome metabólico. MATERIAL Y MÉTODO: Se trata de un estudio transversal realizado a pacientes con síndrome metabólico de la Región de Murcia. Se seleccionaron 53 individuos, 33 con síndrome metabólico y 20 sin él (grupo control). La intervención realizada consistió en la cumplimentación de una encuesta recordatorio y un test para valorar nutricionalmente la ingesta dietética, además de la determinación de variables antropométricas y analíticas que incluyen variables relacionas con la actividad antioxidante. RESULTADOS: La actividad antioxidante en ambos grupos analizados está dentro de los límites normales (1,7 ± 0,2 mmol/l en el grupo control y 1,8 ± 0,1 mmol/l en el grupo con síndrome metabólico; ns). La enzima superóxido dismutasa no presenta diferencias significativas entre ambos grupos. Los valores medios de glutatión reductasa (U/l) son superiores en el grupo control que en los pacientes con SM (p < 0,05). Respecto a los biomarcadores de estrés oxidativo, los valores medios de isoprostanos son superiores en el grupo control (4,9 ± 6,2 ng/ml) que en los pacientes con SM (3,5 ± 3,9 ng/ml; p < 0,05). Los valores de LDL oxidadas tienden a ser superiores en los enfermos con SM (96 ± 23,2 U/l) que en el grupo control (86,2 ± 17,3 U/l), no observándose diferencias significativas. Conclusiones Existe una tendencia a un peor perfil nutricional y bioquímico de los pacientes que presentan síndrome metabólico. También tienden a presentar un mayor grado de estrés

BACKGROUND AND OBJECTIVES: 1) Nutritional assessment of the diet followed by patients with metabolic syndrome, and 2) biochemical analysis of the oxidation-reduction level in patients with metabolic syndrome. MATERIAL AND METHODS: A cross-sectional study was conducted in patients with metabolic syndrome in Murcia. Fifty-three patients, 33 with and 20 without (control group) metabolic syndrome, were selected. The intervention consisted of completion of a recall survey and a test to nutritionally assess dietary intake. Anthropometric and laboratory variables, including those related to antioxidant activity, were also tested. RESULTS: Antioxidant activity was within normal limits in both groups (1.7 ± 0.2 mmol/L in the control group and 1.8 ± 0.1 mmol/L in the metabolic syndrome group) (NS). Superoxide dismutase levels were not significantly different between the groups. Mean glutathione reductase levels (U/L) were higher in the control group as compared to patients with metabolic syndrome (P < .05). As regards oxidative stress biomarkers, mean isoprostane levels were higher in the control group (4.9 ± 6.2 ng/mL) than in metabolic syndrome patients (3.5 ± 3.9 ng/mL) (P < .05). Oxidized LDL values tended to be higher in metabolic syndrome patients (96 ± 23.2 U/L) as compared to the control group (86.2 ± 17.3 U/L), but differences were not significant. CONCLUSIONS: There is a trend to a poorer nutritional and biochemical profile in patients with metabolic syndrome, who also tend to have a greater degree of oxidative stress

Biochemical and nutritional markers and antioxidant activity in metabolic syndrome.

BACKGROUND AND OBJECTIVES: 1) Nutritional assessment of the diet followed by patients with metabolic syndrome, and 2) biochemical analysis of the oxidation-reduction level in patients with metabolic syndrome. MATERIAL AND METHODS: A cross-sectional study was conducted in patients with metabolic syndrome in Murcia. Fifty-three patients, 33 with and 20 without (control group) metabolic syndrome, were selected. The intervention consisted of completion of a recall survey and a test to nutritionally assess dietary intake. Anthropometric and laboratory variables, including those related to antioxidant activity, were also tested. RESULTS: Antioxidant activity was within normal limits in both groups (1.7 ± 0.2 mmol/L in the control group and 1.8 ± 0.1 mmol/L in the metabolic syndrome group) (NS). Superoxide dismutase levels were not significantly different between the groups. Mean glutathione reductase levels (U/L) were higher in the control group as compared to patients with metabolic syndrome (P<.05). As regards oxidative stress biomarkers, mean isoprostane levels were higher in the control group (4.9 ± 6.2 ng/mL) than in metabolic syndrome patients (3.5 ± 3.9 ng/mL) (P<.05). Oxidized LDL values tended to be higher in metabolic syndrome patients (96 ± 23.2U/L) as compared to the control group (86.2 ± 17.3 U/L), but differences were not significant. CONCLUSIONS: There is a trend to a poorer nutritional and biochemical profile in patients with metabolic syndrome, who also tend to have a greater degree of oxidative stress.